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diagnosis differential hemolytic algorithm causes extravascular atlas calculation cold disease index rbc testing workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... . primary cold agglutin ... Hemoglobinopathies (e.g. sickle ... #Hemolytic #Intravascular ... differential #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
• Alloimmune ... Thalassemia • Sickle ... cell • Unstable ... anemia • ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
syndrome, Increased reticulocyte ... - Sickle cell anemia ... , Disseminated intravascular ... #Atlas #key #diagnosis ... #differential #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production ... hemolytic anemia ... defects (e.g. sickle ... cell anemia, G6PD ... #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... (older) • Autoimmune ... the RBCs causing intravascular ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... abnormal RBCs - Reticulocyte ... Differential #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... other reproducible morphologic ... Agglutination - Cold agglutinins ... elliptocytosis, autoimmune ... Algorithm #workup #hematology
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