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Post-Exposure Prophylaxis (PEP) - CDC Guidelines

BIDMC Infectious Diseases Fellowship @BIDMC_IDFellows

#PostExposure #Prophylaxis #PEP #CDC #Guidelines #management #pharmacology
Post-Exposure Prophylaxis ... Guidelines BIDMC Infectious ... BIDMC_IDFellows #PostExposure ... #Prophylaxis #PEP ... CDC #Guidelines #management
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential Diagnosis ... Polycythemia Vera • Chronic ... Myelofibrosis Infectious ... : • Acute or Chronic ... #Differential #Diagnosis
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
- Differential Diagnosis ... deficiency) • Infection ... Sepsis • Non-infectious ... Myelofibrosis • Chronic ... causes #Platelets #hematology
Cerebral Toxoplasmosis 
- Most comrnon CNS infection in patients with AIDS 
who are not receiving appropriate
Most comrnon CNS infection ... receiving appropriate prophylaxis ... • Seizure Management ... pyrimethamine-induced hematologic ... Toxoplasmosis #Diagnosis
IDSA Recommendations for Preventing and Treating Penicillium marneffei Infections in HIV-AIDS
Preventing 1st Episode of Penicilliosis (Primary
Penicillium marneffei Infections ... Treating Acute Infection ... weeks followed by chronic ... Prevention #Treatment #management ... opportunistic #infections
Post-Exposure Prophylaxis (PEP) Monitoring
 • Initial / ED Visit: HIV Ab/Ag, Hep B serologies, HCV Ab,
Post-Exposure Prophylaxis ... HCV Ab - BIDMC Infectious ... BIDMC_IDFellows #PostExposure ... #Prophylaxis #PEP ... #Monitoring #diagnosis
Isolated Neutropenia - Differential Diagnosis Algorithm
Chronic (>3 months):
 • Extrinsic: Vitamins
 • Intrinsic: Congenital, Inflammatory
Transient:
 •
- Differential Diagnosis ... Algorithm Chronic ... Inflammation: Infectious ... , Non-infectious ... #Algorithm #hematology
Interpretation of Hepatitis B Serologies 
HBsAg - HBcAb (total) - HBcAb (IgM) - HBsAb
Susceptible to HBV
Immune
vaccine Acute HBV Chronic ... vs "Low level" chronic ... acute infection ... Serologies #serology #diagnosis ... #hepatology #interpreation
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... • Nonmalignant hematologic ... : Chronic infections ... #Differential #Diagnosis
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
antivirals (DAAs) for chronic ... C virus (HCV) infection ... infectiousdisease #hepatology ... HepC #HepatitisC #Management