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diagnosis nephrology differential causes lupus nephrotic rheumatology syndrome biopsy comparison erythematosus glomerular hematuria indications membranoproliferative mpgn nephritis renal systemic vasculitis
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Syndrome Step ... hematuria and/or proteinuria ... /nephritic syndromes ... dysmorphic RBCs in urine ... #Algorithm #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Persistent Proteinuria ... UTI Orthostatic Proteinuria ... • Fanconi's syndrome ... (MPA) • SLE
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... overt glomerular proteinuria ... Overglomerular proteinuria ... diagnosis #glomerular #proteinuria ... #nephrotic #syndrome
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE) SLE patient develops
Lupus Nephritis ... new: • Proteinuria ... urine sediment ... with evidence of proteinuria ... #diagnosis #algorithm
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... RBC casts, +/- proteinuria ... anti-phospholipid syndrome ... glomerulopathy, radiation nephritis ... , malignant HTN
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... blood cells on urine ... • Hereditary nephritis ... and >3.5g/day (nephrotic ... range) proteinuria
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Infections • Malignancy ... proteinuria, hematuria ... edema, active urine ... proteinuria, dependent ... Malignancy Associated
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
• Hematuria, proteinuria ... diseases, such as SLE ... exposure or Dx of malignancy ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
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