16 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... Nephrotic yndrome—podocyte ... #Nephrotic #Syndromes
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Syndrome Step ... hematuria and/or proteinuria ... /nephritic syndromes ... hematuria (RBC casts ... #Syndrome #Comparison
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Syndrome and Nephritic ... Syndrome == Nephrotic ... Syndrome == Onset ... Syndrome == ... #Syndrome #Nephritic
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... , +/- proteinuria ... anti-phospholipid syndrome ... , malignant HTN
Staphylococcus-associated GlomeruloNephritis - Diagnosis and Management Summary
CLINICAL
 • Nephritic syndrome (Casts)
 • Marked proteinuria (may be
Staphylococcus-associated GlomeruloNephritis ... CLINICAL • Nephritic ... syndrome (Casts ... ) • Marked proteinuria ... (may be nephrotic
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
hemolytic-uremic syndrome ... arbitrarily defined as urine ... cell/white cell casts ... urine sediment ... #nephrotic #syndrome
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
and concentrated urine ... Red blood cell - Glomerulonephritis ... tubulointerstitial nephritis ... tuberculosis Fatty - Nephrotic ... syndrome ("Maltese
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... sydnrome • Pigment ... suggestive of glomerulonephritis ... #Urine #Microscopy
Causes of Hematuria - Differential Diagnosis
Renal:
 - Glomerular - IgA Nephropathy, Thin basement membrane, Alport syndrome,
membrane, Alport syndrome ... , Other glomerulonephritis ... - Interstitial nephritis ... - Physical - Malignancy ... - Structural - Cysts
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
disease - Alport syndrome ... pain hematuria syndrome ... hematuria: - RBC casts ... - Proteinuria ... • Nutcracker syndrome