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diagnosis differential nephrology algorithm causes urology management renal clinical rheumatology syndrome pocus classification glomerular urine kidney lupus nephrotic ultrasound workup
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
the patient has hematuria ... and/or proteinuria ... have glomerular hematuria
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome == Nephrotic Syndrome == Onset - Insidious Edema - ++++ Blood
- Normal/low Proteinuria ... - ++++ Hematuria ... pressure - Raised Proteinuria ... - ++ Hematuria
Glomerular Diseases - Spectrum - Insidious vs Acute - Nephritic (hypertension, hematuria, renal failure) vs Nephrotic
(hypertension, hematuria ... Nephrotic (Heavy proteinuria
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
of Macroscopic Hematuria ... RBC/WBC casts, proteinuria ... #IM #Urology #Hematuria
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
hematuria. ... Proteinuria often ... Massive proteinuria ... Classification #Proteinuria
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria - Differential ... Framework Gross Hematuria ... change • Gross hematuria ... tract source • Hematuria ... Brown urine - Proteinuria
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... Algorithm • Confirm hematuria ... glomerular bleeding (proteinuria ... uw_IMresidency #Hematuria
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... ) - Isolated Hematuria ... ) - Isolated Hematuria ... polyangiitis) - Hematuria ... nephrotic range) proteinuria
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
presentation • Hematuria ... - 97% • Mean proteinuria ... nephrotic range proteinuria
Sickle Cell Disease (SCD) Nephropathy • Cortical Manifestations - Main issue: Hemolysis-associated endothelial
alterations - Proteinuria ... Manifestations - Hematuria
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