11 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade and anticoagulants ... heparin #warfarin #apaxiban ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... Clotting Time, Thrombin ... Rivaroxaban Apixaban ... EricsMedicalLectures/ #Anticoagulants
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... Thrombin, then primes ... #clot #PT #PTT ... anticoagulation #anticoagulant ... #inhibitor #Apixaban
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... Prolonging the PT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... warfarin, direct thrombin
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... - Rivaroxaban, apixaban ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... Jcortesizaguirr #Abnormal
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... 3 d later with normal ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
AST/ALT > ALP: Typical ... ALP > AST/ALT: typical ... - If both are normal ... Coagulation factors: PT ... of ALP • Near normal
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
BP is normal and ... pt not in distress ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... - APTT < 1.5 x normal