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diagnosis hematology clinical coagulation abnormal aptt cardiology differential echocardiogram pocus prolonged ptt 2chamber a2c anatomy anticoagulation apixaban bleeding bruising cardiac
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... Prolonging the PT ... to identify the cause
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... FVa to generate thrombin ... Thrombin, then primes ... #clot #PT #PTT ... anticoagulation #anticoagulant
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
syndrome • Lupus anticoagulant ... discern these causes ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... heparin - Other anticoagulants ... Pre-analytical cause ... drugs e.g. direct thrombin ... aPTT #Prolonged #Causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... Treat primary cause
Apical 2-Chamber (A2C) Window on POCUS Echocardiogram Helpful to distinguish anterior and inferior regional wall motion abnormalities.
Apical 2-Chamber ... (A2C) Window on ... associated LV thrombus ... In this case, severely ... visible mural thrombus
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 Complex Pericardial Effusion with Tamponade on POCUS Echocardiogram - A4C Pt sent to ED c intradialytic hypotension.
Echocardiogram - A4C ... Pt sent to ED c ... Pt has large pericardial ... RA collapse on Apical ... Echocardiogram #A4C
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 Pectoralis Major Rupture Injury during Bench Press Exercise CLINICAL: a rare injury patterns with typical sudden "tear/pop"
Major Rupture Injury ... CLINICAL: a rare injury ... patterns with typical ... majority of these cases ... Followed by PT/OT
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