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diagnosis hematology coagulation anticoagulation aptt differential ptt abnormal causes doac laboratory prolonged testing thrombin warfarin anticoagulants apaxiban apixaban bleeding bruising
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade and anticoagulants ... coagulation #coumadin #heparin ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... Coagulation Tests PT ... Clotting Time, Thrombin ... Time, Ecarin Clotting ... EricsMedicalLectures/ #Anticoagulants
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... K Antagonists, Heparin ... , or Direct Thrombin ... Prolonging the PT
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
at the site of injury ... Thrombin, then primes ... #clot #PT #PTT ... anticoagulation #anticoagulant ... Rivaroxaban #Edoxaban #heparin
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Started on heparin ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus
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 Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
unfractionated heparin ... - Other anticoagulants ... cause e.g. heparin ... drugs e.g. direct thrombin ... inhibitors, heparin
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... 100mg/dL) - Heparin
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver injury ... AST/ALT > ALP: Typical ... ALP > AST/ALT: typical ... Coagulation factors: PT ... replaced by non-hepatic
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... within and above typical ... ECA = ecarin chromogenic ... assay; ECT = ecarin ... clotting time; TT = thrombin
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