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diagnosis hematology differential aptt causes ptt anticoagulation management thrombin warfarin anatomy apaxiban apixaban bleeding bruising cascade chemistry clot coumadin dabigatran
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... and anticoagulants ... #coumadin #heparin ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... Step 1: Is the PT ... Patient Receiving Anticoagulants ... K Antagonists, Heparin ... , or Direct Thrombin
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Effect of Anticoagulants ... on Coagulation ... Tests PT / INR, ... Clotting Time, Thrombin ... EricsMedicalLectures/ #Anticoagulants
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... - Other anticoagulants ... drugs e.g. direct thrombin ... Jcortesizaguirr #Abnormal ... #PT #aPTT #Prolonged
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor and lupus anticoagulant ... syndrome • Lupus anticoagulant ... PT/ABNORMAL PTT ... deficiency • Anticoagulants ... deficiency • Anticoagulant
Paracentesis Anatomy Landmarks Don't hit the inferior epigastric artery!!! Go 2cm below the umbilicus in the midline
spine Overall coagulation ... cirrhosis, despite abnormal ... tests of coagulation ... Prolonged PT) because ... procoagulants and anticoagulants
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... at the site of injury ... #clot #PT #PTT ... anticoagulation #anticoagulant ... Rivaroxaban #Edoxaban #heparin
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
drugs (e.g. direct thrombin ... inhibitors, heparin ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... differential #hematology #coagulation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
AST/ALT > ALP: Typical ... - If both are normal ... • Albumin • Coagulation ... factors: PT/INR ... replaced by non-hepatic
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