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coagulation diagnosis causes dic intravascular abnormal anticoagulant anticoagulation apixaban aptt cascade clinical clots dabigatran differential echocardiogram heparin inhibitor intransit isth
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
• Elevation in thrombin ... the presence of thrombin ... can accelerate thrombin ... broken down by thrombin ... to form clots,
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... large amounts of thrombin ... Cascade #platelet #thrombin ... #clot #PT #PTT
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... Echocardiogram #A4C ... PulmonaryEmbolism #Thrombus ... #Clots #InTransit
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 Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Rivaroxaban, apixaban, edoxaban ... drugs e.g. direct thrombin ... Disseminated intravascular ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... significant fibrin clot ... treatment #management #hematology
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