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diagnosis hematology causes differential aptt clinical clots dic echocardiogram intransit intravascular mcconnells pocus prolonged sign algorithm anticoagulant anticoagulation apixaban bleeding
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... platelet aggregation PT ... using INR use PT ... to form clots, ... vessels #DIC #Disseminated
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... significant fibrin clot
Cool echo - RV strain, McConnell sign, and CLOT IN TRANSIT!! BP is normal and pt
McConnell sign, and CLOT ... BP is normal and ... pt not in distress ... Echocardiogram #A4C ... Pulmonary #Embolism #Thrombus
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 The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... Jcortesizaguirr #Abnormal
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
Thrombus in transit ... Pt had extensive ... 3 d later with normal ... Echocardiogram #A4C ... #Clots #InTransit
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 Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... amyloidosis #Abnormal ... differential #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... warfarin, direct thrombin
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Retained blood clots ... succenturiate lobe • Abnormal ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation
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