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hematology abnormal algorithm aptt arterial blanching bleeding bruise bruising dic disorders ecchymosis embolism emergencies hematomas hemeonc hemorrhage hemostasis inr intravascular
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PT (INR), Prolonged ... Differential #Diagnosis ... #Algorithm #Causes ... #Hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... #Causes #diagnosis ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... #Causes #diagnosis ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Diagnosis Algorithm ... fatigue (e.g. prolonged ... or percreta) Thrombin ... HELLP syndrome • Disseminated
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... Diagnosis Framework ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... prolonged after ... liver failure, disseminated ... discern these causes ... warfarin, direct thrombin
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... Excessive bruising & prolonged ... to be normal, PT ... Diagnosis VWF ... VWF:RCo/VWF:Ag (differentiate
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... “big & sticky” cells ... Oncology #HemeOnc #Diagnosis
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