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diagnosis hematology abnormal aptt prolonged algorithm arterial blanching bleeding bruise bruising dic ecchymosis embolism emergencies hematomas hemeonc hemorrhage hemostasis management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #Intravascular
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation ... #Obstetrics #OBGyn
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... #diagnosis #differential ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes ... pathophysiology #hematology #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... warfarin, direct thrombin
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... in endothelial cells ... to be normal, PT ... VWF:RCo/VWF:Ag (differentiate
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
fever: - Fever + ANC ... first) DIC (disseminated ... intravascular coagulation ... Treat underlying cause ... “big & sticky” cells
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