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diagnosis hematology differential causes dic abnormal aptt pathophysiology prolonged smear algorithm anemia anticoagulant anticoagulation apixaban arterial blanching bleeding blood bloodsmear
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... Intravascular Coagulation ... platelet aggregation PT ... using INR use PT ... #Intravascular
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #Intravascular
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... differential #hematology #coagulation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... LaboratoryFindings #Disseminated ... #Intravascular ... #Coagulation #Labs
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
polychromatophilic cells ... conditions such as disseminated ... intravascular coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Aortic mural thrombus ... Cardiac: - Atrial thrombus ... Left ventricular thrombus ... thrombocytopenia - Disseminated ... intravascular coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation ... (DIC) • Anti-coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... differential #hematology #coagulation
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
fragmented red blood cells ... schizocytes, these cells ... shapes of red cells ... phenomenon include disseminated ... intravascular coagulation
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