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diagnosis differential management abnormal blood disseminated intravascular product prolonged reactions anticoagulant anticoagulation apixaban bleeding bruising cardiology cascade clinical clot constrictive
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
(DIC) Platelet ... platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... Scoring #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... drugs e.g. direct thrombin ... (DIC) c. ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... drugs (e.g. direct thrombin ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... diagnosis #models #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... discern these causes ... disease • Acute DIC ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology
Constrictive Pericarditis on POCUS Echocardiogram - Subcostal View Young Lupus patient admitted to hospital new onset HFpEF.
could pinpoint the cause ... Also has pericardial ... one month ago-pt ... Did have tap next ... clinical #cardiology #s4C
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 Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Causes purpura & ... potassium from lysed cells ... RBCs (stored at 4C ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... Causes purpura & ... potassium from lysed cells ... RBCs (stored at 4C ... diagnosis #management #hematology
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