48 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... @DharSaty #coagulation ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
POCUS Echocardiography - Table of Cardiac Views and Windows
 • Parastemal Long-Axis View (PLAX)
 • Parasternal
Echocardiography - Table of Cardiac ... -Chamber View (A4C ... Aortic Valve (AV) Level ... Mitral Valve (MV) Level ... Anatomy #POCUS #Cardiac
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... platelet aggregation PT ... consumption of coagulation ... using INR use PT ... Intravascular #Coagulation
Mitral Stenosis and Left Atrial Thrombus on Echocardiogram (a4c)

Mitral stenosis is a risk factor for LA
and Left Atrial Thrombus ... Echocardiogram (a4c ... factor for LA thrombus ... of underlying cardiac ... #a4c #Echocardiogram
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Congenital intrinsic coagulation ... drugs e.g. direct thrombin ... Reduced liver synthesis ... intravascular coagulation
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Anticoagulants on Coagulation ... Tests PT / INR, ... Clotting Time, Thrombin
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... Thrombin, then primes ... #Coagulation #Cascade ... #platelet #thrombin ... #clot #PT #PTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... DIC • Severe Liver
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Syndrome, Ischemic Liver ... Paradoxical Embolism • Cardiac ... : - Atrial thrombus ... valves - Infected cardiac ... intravascular coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... == NORMAL PT ... • Factor VIII level ... intravascular coagulation ... warfarin, direct thrombin