10 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... coagulation #coumadin #heparin ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... K Antagonists, Heparin ... , or Direct Thrombin ... Prolonging the PT ... #prolonged #diagnosis
Coagulation Cascade Mnemonic - PITT vs PET
PITT (with an I) = Intrinsic = APTT
Coagulation Cascade ... (with an I) = Intrinsic ... = APTT Factors ... E)= Extrinsic=PT ... Mnemonic #PITT #PET #diagnosis
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... along with FXIIa (intrinsic ... #clot #PT #PTT ... #diagnosis #models ... Rivaroxaban #Edoxaban #heparin
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... Started on heparin ... Echocardiogram #A4C
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... inhibitors, heparin
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... Congenital intrinsic ... drugs e.g. direct thrombin ... inhibitors, heparin ... #Causes #diagnosis
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Clotting Time, Thrombin ... Time, Ecarin Clotting ... Anticoagulation #Testing #Diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... integrity Clotting cascade ... Acquired: • Heparin ... pathway to the intrinsic ... warfarin, direct thrombin
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #Coagulation #diagnosis