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coagulation abnormal causes differential prolonged disseminated intravascular ptt anticoagulation apixaban bleeding bruising cascade clot dabigatran edoxaban evaluation hemostasis heparin inhibitor
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Heparin, or Direct Thrombin ... #prolonged #diagnosis ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
heparin - Other anticoagulants ... Congenital intrinsic ... drugs e.g. direct thrombin ... #Causes #diagnosis ... #differential #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... Warfarin • Acute DIC ... disease • Acute DIC ... warfarin, direct thrombin ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... intravascularcoagulation (DIC ... #differential #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Increased thrombin ... Reduction of pro/anticoagulants ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... treatment #management #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
along with FXIIa (intrinsic ... #clot #PT #PTT ... #diagnosis #models ... #hematology #pathophysiology ... anticoagulation #anticoagulant
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