8 results
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
/ PT - Differential ... Diagnosis Algorithm ... aPTT: Intrinsic ... #Hematology #differential ... #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Congenital intrinsic ... drugs e.g. direct thrombin ... #Causes #diagnosis ... #differential # ... hematology #coagulation
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
platelet aggregation PT ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Diagnosis Algorithm ... 12-13 g/dL, • ANC ... iron studies, PT ... /aPTT Differential ... #hematology #workup
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #Coagulation #diagnosis ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... disease • Acute DIC ... warfarin, direct thrombin ... #Diagnosis #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
along with FXIIa (intrinsic ... Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... #hematology #pathophysiology