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coagulation differential causes abnormal dic pathophysiology prolonged anticoagulant anticoagulation apixaban arterial bleeding bruising cascade clot dabigatran edoxaban hemostasis heparin inhibitor
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... , aPTT: • Expected ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... drugs e.g. direct thrombin ... Disseminated intravascular ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... #differential #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... thrombocytopenia - Disseminated ... intravascular coagulation ... pathophysiology #hematology ... #differential #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... #Coagulation #diagnosis ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin ... #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
along with FXIIa (intrinsic ... Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... #hematology #pathophysiology
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