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hematology causes abnormal aptt dic disseminated intravascular prolonged anticoagulants anticoagulation bleeding bruising clots echocardiogram effects erythematosus hemostasis intransit isth lupus
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... platelet aggregation PT ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Anticoagulants on Coagulation ... Tests PT / INR, ... Clotting Time, Thrombin ... Anticoagulation #Testing #Diagnosis ... #Laboratory #Effects
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... organ damage Clinical ... venipuncture sites Laboratory ... #diagnosis #causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
drugs e.g. direct thrombin ... intravascular coagulation ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
This 24M presented with acute onset CP/SOB, hypoxia, HR 150s. What's the diagnosis? Treatment options? Hint:
What's the diagnosis ... Thrombus in transit ... Pt had extensive ... #Clinical #POCUS ... Echocardiogram #A4C
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 Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... inhibitor of a coagulation ... warfarin, direct thrombin ... #Diagnosis #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... and fever) and laboratory ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Erythematosus #Diagnosis
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