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hematology coagulation anticoagulation causes differential disseminated intravascular abnormal anticoagulant aptt bleeding bruising cascade clot dabigatran edoxaban effects hemostasis heparin hepatic
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... Clotting Time, Thrombin ... Rivaroxaban Apixaban ... Anticoagulation #Testing ... #Diagnosis #Laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
platelet aggregation PT ... using INR use PT ... to form clots, ... ISTH #Scoring #diagnosis ... #hematology #laboratory
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
Thrombin, then primes ... #clot #PT #PTT ... #diagnosis #models ... anticoagulation #anticoagulant ... #inhibitor #Apixaban
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Increased thrombin ... venipuncture sites Laboratory ... significant fibrin clot ... Reduction of pro/anticoagulants ... #Coagulation #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... Warfarin • Acute DIC ... fibrinogen levels, and testing ... disease • Acute DIC ... warfarin, direct thrombin
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... liver glycogen stores ... - Prolonged PT ... As a result of DIC ... #Diagnosis #Testing
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... intravascular coagulation (DIC ... Prolonged #Causes #diagnosis
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