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REBEL Review 4 & 5: Paralytic & Vasopressor Dosing 

Paralytic Agents:
 - Succinylcholine (Depolarizing Agent)
Paralytic Agents ... (Depolarizing Agent ... Dopamine - Phenylephrine ... vasopressors #paralytics #agents
Push Dose Pressors - Mixing Instructions - Epinephrine and Phenylephrine

Epinephrine Preparation steps:
1. Add 9 mL of
Epinephrine and Phenylephrine ... Label syringe Phenylephrine ... remove 1 mL from phenylephrine ... bag containing phenylephrine ... #CriticalCare #PushDose
Vasoactive Agents - Receptor Profiles
Adrenergic Profile: α → β
phenylephrine, norepinephrine, dopamine, epinephrine, dobutamine, isoproterenol

- Dr. Rishi
Vasoactive Agents ... Profile: α → β phenylephrine ... #Vasoactive #Agents
Push Dose Pressors - Mixing Instructions.

EPINEPHRINE
Has alpha and beta 1/2 effects so it is an inopressor
Do
(5-20 mcg) PHENYLEPHRINE ... draw up 1 ml of phenylephrine ... (vial contains phenylephrine ... have 100 mls of phenylephrine ... #CriticalCare #PushDose
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
Vasopressors Phenylephrine ... Preferred first agent ... • Higher doses cause ... alpha-effect • 1st agent ... cAMP/cGMP • Causes
Causes of Nausea and Vomiting - Differential Diagnosis Framework

Chemoreceptor Trigger Zone/Area Postrema:
 • Drugs:
	- Chemo agents
	-
Causes of Nausea ... Drugs: - Chemo agents ... Cardiovascular agents ... Malignancy #nausea ... differential #diagnosis #causes
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
potential causative agents ... chlorhexidine as cause ... lubricants, cleansing agents ... as a possible cause ... possible trigger agents
Causes of Myocarditis
Infectious Etiologies:
 • Viral agents: Adenoviruses, Enteroviruses (coxsackievirus), Herpesviruses (human herpesvirus 6, Epstein—Barr virus),
Causes of Myocarditis ... Etiologies: • Viral agents ... B19 • Parasitic agents ... pallidum • Fungal agents ... diagnosis #cardiology #causes
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... elliptocytosis Extrinsic Causes ... Malaria • Oxygen agents ... nitrates • Other agents ... Intravascular Causes
Secondary Causes of Hypertension
Renal hypertension 
Endocrine hypertension 
Cardiovascular hypertension 
Neurogenic hypertension 
Hypertension in pregnancy 
Toxic agent-induced
Secondary Causes ... pregnancy Toxic agent-induced ... #Differential #Causes