93 results
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
• Rickettsial diseases ... Intermittent tertian: P. vivax ... • Crohn disease ... • Behcet disease ... Non-Infectious Causes
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... symptoms - Headache, fever ... , fatigue, Nausea ... Urticaria #diagnosis #rheumatology ... #comparison #table
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... #Syndrome #Treatment ... #management #pharmacology ... #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... autoinflammatory diseases ... diagnosis #management #treatment ... #rheumatology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Fever: • Regulated ... production • Treatment ... rapidly fatal • Causes ... #Hyperthermia #comparison
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
in Sickle Cell Disease ... number of pain crises ... (2.4 vs. 1) • Fewer ... 35% vs. 24%) • Fewer ... pathophysiology #pharmacology
Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease
CDC Case Definition for MIS-C;
 • < 21
Kawasaki Disease ... CDC Case Definition ... years old with fever ... other reasons for disease ... MISC #Kawasaki #Comparison
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... deficiency • Liver disease ... Von Willebrand disease ... mountain spotted fever ... #rheumatology #
Causes of Pericardial Effusion - Differential Diagnosis
Infectious:
 • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus
 • Bacterial: Mycobacterium
Causes of Pericardial ... Non-Infectious: • Rheumatologic ... Mediterranean Fever ... : EGPA, Horton Disease ... , Takayasu Disease
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... : High spiking fever ... Systemic AOSD: high fever ... synovitis (40%) Treatment ... #AOSD #rheumatology