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management hematology classification treatment vasculitis adultonset cd4 creatine derm disease elevated erythematosus framework gravis hemophagocytic hlh hodgkins icl idiopathic kinase
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
(COVID19, CMV/EBV ... myopathy - Autoimmune ... tissue disorder, SLE ... #differential # ... diagnosis #rhabdomyolysis
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Viral: HIV, HCV, EBV ... : ITP, HITT - Autoimmune ... : SLE, RA, antiphospholipid ... #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... arthritis, Skin rash ... fraction < 20% Differential ... Muscular: normal CK ... management #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... solid cancers • Autoimmune ... diseases: SLE++ ... treatment #summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... disease • Non-autoimmune ... rheumatologic diseases ... #Rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis is an autoimmune ... Hodgkin lymphoma - Autoimmune ... rheumatoid arthritis, SLE ... life-threatening Differential ... myasthenia Diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
W/ LOW CD4 • Autoimmune ... (Sjogren, SLE, ... EBV. CMV. ... #hematology #Differential ... #Causes #lymphocytopenia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis Framework ... tract, and often causes ... mucositis - Rash ... vasculitis, and SLE ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Immunosuppression • Autoimmune ... Hodgkin Lymphoma - Clinical ... lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate
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