10 results
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Viral: HIV, HCV, EBV ... : ITP, HITT - Autoimmune ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... reticularis Differential ... • Goodpasture syndrome ... #dermatology #rash
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... #Neutropenia #differential ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... #ProteinGap #differential ... #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... - Mycoplasma, EBV ... younger pts) Differential ... hemolytic #anemia #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... mucositis - Rash ... #diagnosis #rheumatology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
W/ LOW CD4 • Autoimmune ... chemotherapy) • Genetic syndromes ... ICL #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... MPO > PR3 60/ GPA ... tract, and often causes ... #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Immunosuppression • Autoimmune ... Hodgkin Lymphoma - Clinical ... Immunohistochemical studies (to differentiate ... classification #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #