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diagnosis hematology differential cd4 common cryofibrinogenemia cvid framework gammopathies gap globulin hypogammaglobulinemia icl idiopathic immunodeficiency immunology lymphocytopenia lymphopenia management mgus
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Viral: HIV, HCV, EBV ... : ITP, HITT - Autoimmune ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
gamma gap (total protein ... Causes of false- ... plasmacytoma, POEMs syndrome ... macroglobulinemia, and autoimmune ... MGUS #diagnosis #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... replacing the BM ... replacing the BM-common ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
DDX - Other causes ... : • Nephrotic syndrome ... • Burns • Protein-losing ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
and other plasma proteins ... associated with autoimmune ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... differential #diagnosis #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
W/ LOW CD4 • Autoimmune ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... ICL #diagnosis #hematology ... #Differential #Causes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, mucositis • Rash ... with elevated protein ... tract, and often causes ... pain and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... Myositis #Myopathy #rheumatology
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