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diagnosis hematology vasculitis agglutinin algorithm anemia bruising classification cold erythematosus gap globulin hemeonc hemolytic hemophagocytic hepatitis hepatology hlh icl idiopathic
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
• Autoimmune ... chemotherapy) • Genetic syndromes ... EBV. CMV. ... #Differential # ... Causes #lymphocytopenia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... Erythematosus #Diagnosis #Rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... HBV, HCV, HEV, EBV ... • Autoimmune:
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral infection, autoimmune ... hemolysis • C3↓ C4 ... - Mycoplasma, EBV ... pts) Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... tract, and often causes ... mucositis - Rash ... Differential ... #diagnosis #rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... Congenital heart disease ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... tract, and often causes ... pain and GN Anti-GBM ... #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... statins - probably caused ... #differential #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... changes (POEMS syndrome ... acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... Gap #ProteinGap #differential
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Infections (e.g., EBV ... Malignancies ▪ Autoimmune ... diseases (often ... of NK cells and CD8
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