13 results
Mortality after Fluid Bolus in African Children with Severe Infection - June 30, 2011 N Engl
NEJMoa1101549 #EBM ... #Peds #Pediatrics ... #FEAST #Trial #IVFluids ... Boluses #Africa #NEJM
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... Emboli, Thrombosis, Vasculitis ... GN: ANCA, Anti-GBM ... #AKI #Acute #Kidney ... Diagnosis #nephrology #causes
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... tubular necrosis (causes ... : sepsis, meds, ... #AKI #Acute #Kidney
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... • Limited to Kidney ... : Anti-GBM Glomerulonephritis ... involvement: Anti-GBM ... Glomerulonephritis #Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... glomerulonephritis) • Anti-GBM ... Polyarteritis Nodosa: - Kidneys ... mucositis - Rash ... Kidneys -> glomerulonephritis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... osmolarity If cause ... Glomerulonephritis / Vasculits ... ANCA, ANA, Anti-GBM ... imaging #Acute #Kidney
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Infectious: Influenza, EBV ... Bacteremia, Sepsis • Kidneys ... PMR, RA, SLE, Vasculitis ... Differential #Diagnosis #causes
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis - Kupperman et al. NEJM 2018

https://www.nejm.org/doi/full/10.1056/NEJMoa1716816
Study
NEJM 2018 https ... TessaRDavis #EBM ... VisualAbstract #Peds ... Pediatrics #DKA #IVFluids ... Infusion #Rates #NEJM
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... potential inciting causes ... Haverhill fever caused ... Rash is usually ... of necrotizing vasculitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... musculoskeletal systems • Kidneys ... , mucositis • Rash ... tract, and often causes ... pain and GN Anti-GBM