15 results
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
III: Diffuse, Renal ... crisis, Rapid progressive ... , Overlap BCM IM ... Autoantibodies #diagnosis #rheumatology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
• Scleroderma renal ... crisis • Severe ... Catastrophic APLS BCM IM ... differential #diagnosis #hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Care TRICC - NEJM ... 2013 - UGIB TRISS ... TRICS3 - NEJM ... unnecessary and cause ... Transfusion #Thresholds #Hematology
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
calcification of both adrenal ... and gut, which causes ... #clincial #peds ... #adrenal #calcifications ... #infant #NEJM #
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... 21-OHD in the adrenal ... • Salt wasting crisis ... as "congenital adrenal ... endocrinology #peds
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
especially in the wrists ... everywhere) 2) A rash ... 6) An annular rash ... 7) Always in case ... erythematosus #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Hydroxychloroquine - Risks ... Polyautoimmunity Risks ... rare with ~100 cases ... of renal or hepatic ... #sideeffects #rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Crisis (SRC) ... Crisis: 1) Acute ... , add other BP meds ... • Refractory cases ... #Crisis #rheumatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
• Hypertensive crisis ... Immunosuppressive agents, Renal ... the underlying cause ... Seizures: Treat with AEDs ... until cause identified
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
pulmonary and renal ... tract, and often causes ... mucositis - Rash ... • Urinalysis (Renal ... differential #diagnosis #rheumatology