17 results
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Major Clinical Trials ... Transfusing blood ... Blood saves lives ... unnecessary and cause ... Transfusion #Thresholds #Hematology
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
calcification of both adrenal ... and gut, which causes ... #clincial #peds ... #adrenal #calcifications ... #infant #NEJM #
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Photosensitivity, Butterfly rash ... Abdominal pain (20%) Renal ... Glomerulonephritis Myositis(5%) Blood ... symptoms #diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Maculopapular rash ... vasculitis (inflamed blood ... #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... auricular papules Clinical ... onset [33-74%] • Blood ... Dermatomyositis #rheumatology
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death Common Clinical ... depressed) • Renal ... anaphylaxis, toxins/meds ... O2 delivery • PE ... #differential #causes
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death Common Clinical ... depressed) • Renal ... anaphylaxis, toxins/meds ... O2 delivery • PE ... #differential #causes
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... organ damage Clinical ... Bleeding (64%) • Renal ... Treat primary cause ... Coagulation #diagnosis #causes