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rheumatology management sle algorithm dermatology erythematosus nephrology pathophysiology pulmonary renal syndrome systemic workup acute aki arteritis autoimmune classification complications edema
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Glomerulonephritis Myositis(5%) Blood ... erythematosus #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... endothelium) & Decr blood ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... Diagnosis Algorithm ... (lupus, RA, Sjogren's ... #Differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria - Differential ... urine • 1ml blood ... hematuria • Signs ... GN or vasculitis ... #Diagnosis #causes
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Diagnosis Baseline ... osmolarity If cause ... clinical context and signs ... Glomerulonephritis / Vasculits ... #causes
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework High Altitude Pulmonary Edema: • Accumulation
Edema (NCPE) - Differential ... Diagnosis Framework ... • Signs/Symptoms ... • Signs/Symptoms ... diagnosis #NCPE
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Diagnosis Approach ... hypertension and signs ... bruit or signs ... Coarctation of aorta, Vasculitis ... #Differential #
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... endothelial lining of blood ... periumbilical region), nausea ... Pathophysiology #Diagnosis ... #Signs #Symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... APLA/LAC: • Renal ... : • Symptoms limited ... Erythematosus #Diagnosis
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