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differential rheumatology dermatology druginduced erythematosus management signs systemic vasculitis arthropathies arthropathy autoantibodies classification clinicopathology compared complications dil disorders endocarditis erythemas
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... NPSLE rare, Malar rash ... Manifestations: Malar rash ... Positive in 60-80% of cases ... #sle #comparison
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... plugging -> Discoid Rash ... Malar (butterfly) Rash ... #signs #symptoms
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... Algorithm Vesicles ... Bullous systemic lupus ... Vesiculobullous #SkinRash ... #Algorithm #causes
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... involvement 3% SLE-Related ... , Cutaneous mimickers ... Lupusreference #SLE ... autoantibodies #signs #symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... evidence of (fatigue, rash ... eruption - Butterfly rash ... rash • Erythematous ... Photosensitivity • Malar rash
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... Algorithm Monoarthritis ... Erythematosus (SLE ... should have other symptoms ... like “butterfly rash
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... - Differential Diagnosis ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #Algorithm #causes
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... Constitutional symptoms ... NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... #rheumatology #diagnosis
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
Rash is usually ... chronicum migrans • Rash ... Fever + facial rash ... • Evanescent rash ... Acute systemic rash
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Most common extra cutaneous ... Causes: - Idiopathic ... ’s syndrome - Lupus
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