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dermatology differential lupus management myositis sle autoimmune erythematosus myopathy systemic activation antimda5 antimda5dm antinxp2 antinxp2dm cutaneous dermatologic druginduced eschar gottronspapules
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Antiphospholipid-antibody syndrome ... #differential #diagnosis ... #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... can present with rash ... including heliotrope rash ... anti-synthetase syndrome ... #rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... auricular papules Clinical ... #rheumatology # ... dermatology #diagnosis
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... pain and/or joint aches ... #differential #diagnosis ... #comparison #rheumatology
Dermatomyositis with heliotrope rash, shawl sign, and Gottron's papules A middle-aged man describes progressive difficulty combing his
with heliotrope rash ... 1) heliotrope rash ... #heliotrope #skinrash ... #dermatology #clinical ... #photo
Cutaneous larva migrans skin Rash 25 F recent Caribbean vacation, walked barefoot on sand and now with
larva migrans skin Rash ... now with creepy rash ... migrating serpiginous rash ... larva #migrans #skinRash ... #photo
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... signs #symptoms #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... eruption - Butterfly rash ... Photosensitive rash ... Still disease, dermatomyositis ... Photosensitivity • Malar rash
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... Petechial or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
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