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diagnosis erythematosus differential management systemic activation autoantibodies classification dil hematology imdamnsharp mas mimickers mnemonic myopathies myopathy signs symptoms syndrome system
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Anti-phospholipid) M Malar Rash ... D Discoid Rash ... Antinuclear Antibody (ANA ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... muscle weakness, rash ... uncommon 5-15% of lupus ... differential #diagnosis #comparison ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... Lupusreference #druginduced ... #lupus #sle #comparison ... #table #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... annular rash on ... #diagnosis #sle ... #clues #system ... erythematosus #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... anemia 4% - Myositis ... Auto-Antibodies: - ANA ... Lupusreference #SLE ... #differential #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... evidence of (fatigue, rash ... eruption - Butterfly rash ... Photosensitive rash ... Photosensitivity • Malar rash
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... Petechial or purpuric rash ... SJIA], systemic lupus ... erythematosus [SLE ... #Rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... Workup: - ANA ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Rash, arthritis ... such as systemic lupus ... LFT • ESR • ANA ... SLE) • Urinalysis ... differential #diagnosis #rheumatology
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