10 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 69% - Malar rash ... #Systemic #Lupus ... autoantibodies #signs ... #differential #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... , Fever, Malar rash ... , Oral ulcers, Rash ... #SLE #Signs #Symptoms ... #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... #SLE #systemic ... erythematosus #signs
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... months to years) Systemic ... Manifestations: Malar rash ... #sle #comparison ... #table #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... evidence of (fatigue, rash ... eruption - Butterfly rash ... Photosensitive rash ... Photosensitivity • Malar rash
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
arthritis (sJIA) • Adult-onset ... lupus erythematosus ... Petechial or purpuric rash ... [SLE], AOSD) • ... #Rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... can present with rash ... including heliotrope rash ... anti-synthetase syndrome ... Myositis #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
mucositis - Rash ... lupus erythematosus ... purpura: strong sign ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... , mucositis • Rash ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
cancer-associated adult ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system