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diagnosis disease lupus sle adultonset aosd erythematosus signs symptoms systemic treatment activation adult autoantibodies druginduced fungal gca giantcell hematology infections
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Fever, Arthralgia/arthritis ... , Skin rash ± odynophagia ... fraction < 20% Differential ... Disease #diagnosis #management ... #treatment #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... maculopapular rash ... #AdultOnset #Stills ... Disease #AOSD #rheumatology ... #diagnosis #management
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
muscle weakness, rash ... with temporal arteritis ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... 69% - Malar rash ... (aPL) 30-45% Differential ... Multiple sclerosis, Still's ... #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... early evening • Arthritis ... Arthralgias or arthritis ... AOSD #diagnosis #rheumatology ... #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... NPSLE rare, Malar rash ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... • Adult-onset Still ... Petechial or purpuric rash ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... very remarkable w/differential ... identifies 85 to 95% of cases ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... permanent alopecia Differential ... , adult-onset Still ... Non-autoimmune rheumatologic ... Erythematosus #Diagnosis #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fever, cough, chills ... pulmonary symptoms • Rheumatologic ... , muscle aches, ... Meningitis, septic arthritis ... Fungal #Diagnosis #Management
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