7637 results
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
RBC are produced ... Approximately 1% of RBC ... destruction of RBC ... well as varying clinical ... Mentzer index = (MCV/RBC
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Clinical Presentation ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Lutzomyia verrucarum Clinical ... anorexia, ARDS ​• RBC ... severe hemolytic anemia ... toxo reactivation Clinical ... coccobacillus within the RBCs
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... • Symptoms of anemia ... • hemolytic anemia ... Blood smear - RBC ... red blood cells (RBCs
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Pathogenesis and clinical ... Serum PO4 -> decr RBC ... hemolysis - anemia
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... / Normochromic RBCs ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Spherocytes, RBC ... Microangiopathic Hemolytic Anemias ... ) - Abnormal RBCs ... #Normocytic #Anemia
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... #Hemolytic #Anemias
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... iron deficiency anemia
Babesiosis on Peripheral Smear
85 M from SE USA, hx splenectomy, IgG4 plasmacytic syndrome: F, chills, profound
clindamycin & quinine, rbc ... inclusions, improved clinically ... inclusions >10%RBC ... lysis: fever, anemia ... babesia #microti #clinical