55 results
Hemolysis Classification - Intrinsic and Extrinsic Causes

Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... and Extrinsic Causes ... hemolytic transfusion reactions ... #Hemolysis #Classification ... #Algorithm
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
hypersensitivity reaction ... anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation ... #Anaphylaxis #pathophysiology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Allergen-specific lgE causes ... to complement activation ... Acute transfusion reaction ... allergy #table #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
to complement activation ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... Allergy #Diagnosis #Reactions
Pathophysiology Based Approach to Hyponatremia - Diagnostic Algorithm

Not the "classic" Volume based approach. 

#Hyponatremia #Algorithm #Pathophysiology
Pathophysiology ... Hyponatremia - Diagnostic Algorithm ... Not the "classic ... #Hyponatremia #Algorithm ... #Pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... : CLASS 1 - Sodium ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Delayed autoimmune reaction ... with host -> Activation ... RheumaticFever #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
exposure to allergen causes ... Allergic reaction ... because T-Cell activation ... Allergy #Immunology #pathophysiology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... blood donor • Pathophysiology ... sequestration and activation ... transfusion • Pathophysiology ... #Transfusion #Reactions
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... elliptocytosis Extrinsic Causes ... Intravascular Causes ... • Transfusion reactions ... #classification