20 results
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Vaughan Williams Classification ... : CLASS 1 - Sodium ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Pathophysiology Based Approach to Hyponatremia - Diagnostic Algorithm

Not the "classic" Volume based approach. 

#Hyponatremia #Algorithm #Pathophysiology
Pathophysiology ... Not the "classic ... #Hyponatremia #Algorithm ... #Pathophysiology ... #Differential #Nephrology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... • ↓ slope of phase ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
but in severe cases ... Nephrotic #Syndromes #Classification ... #Proteinuria #Nephrology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... sympathetic + ADH activation ... Classification: ... essential in all cases ... Syndrome #Hepatology #Nephrology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Allergen-specific lgE causes ... Course: Immediate-phase ... minutes, Late-phase ... to complement activation ... allergy #table #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... are present • Classic ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #differential #algorithm
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... • 75-90% of cases ... monophasic Pathophysiology ... • Excessive activation ... Abnormal in 50% of cases
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
FLAGS - In all cases ... splenomegaly, abnormal neurology ... #Limping #NWB #Algorithm
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... • 49 million cases ... cytokines, complement activation ... all suspected cases