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Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... Extravascular Hemolysis Reticulocytes ... Anemia #Laboratory #Testing ... workup #diagnosis #hematology
Calculating a Reticulocyte Index (RI) Reticulocyte Index = Absolute Reticulocyte Count / Maturation Correction Absolute Reticulocyte Count =
Calculating a Reticulocyte ... Index (RI) Reticulocyte ... Index = Absolute Reticulocyte ... Count = % of reticulocytes ... Index #RI #RPI #hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
peripheral smear, reticulocyte ... Production (↓ reticulocytes ... (hemolysis, ↑ reticulocytes ... Diagnosis #Algorithm #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
labs: CBC, BMP, Reticulocytes ... schistocytes > 1% • ↑ Reticulocyte ... Management #Algorithm #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... percentage of reticulocytes ... Corrected reticulocyte ... count OR reticulocyte ... Diagnosis #Workup #Hematology
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome Indirect Hyperbilirubinemia: - Trauma, Hematoma,
, Haptoglobin, Reticulocyte ... , Haptoglobin, Reticulocyte ... Diagnosis #Algorithm #hepatology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
of: Decreased Reticulocytes ... Normal / Decreased Reticulocytes ... Destruction - Increased Reticulocytes ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... EricsMedicalLectures/ #Reticulocyte ... Production #Index #hematology
Laboratory methods for evaluation of coagulation disorders- primary and secondary hemostasis #Laboratory #Testing #Hemostasis #Coagulation #Hematology #Diagnosis
#Laboratory #Testing ... #Coagulation #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
bilirubin • ↑ Reticulocytes ... Diagnosis #Algorithm #hematology
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