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Acyclovir - Pharmacology Summary • Mechanism of Action: Nucleoside analog - selectively inhibits viral replication of
Acyclovir - Pharmacology ... Nucleoside analog - selectively ... TheIDtrivia #Acyclovir
The algorithm below shows how pre-test probability could be combined with various criteria to determine which
require empiric acyclovir ... short course of treatment ... favor the use of acyclovir ... provide empiric treatment ... -Acyclovir is nephrotoxic
Varicella (Chickenpox) - Crops of vesicles in various stages of healing Treatment • Healthy g 12
of healing Treatment ... Immunocompromised or > 12: Acyclovir
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
NSAID Selectivity ... effects #NSAIDs #selectivity
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 Urine Microscopy - Kidney Stones and Crystals Uric Acid, Cystine, Hippurate, Cloth Fiber, Tyrosine, CaOx, CaP,
CaCO3, Struvite, Acyclovir
Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa - Interaction
- LMWH selectively
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
β-lactam agents, Aciclovir
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Methotrexate, Orlistat, Acyclovir
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Crystal nephropathy: Acyclovir
Pharmacologic Treatments of Chronic Hypertension in Pregnancy Central alpha-agonists - Methyldopa - Clonidine Combined alpha- and beta-blocker -
Pharmacologic Treatments ... Pregnancy #Management #Treatment
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