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treatment differential neurology syndrome dermatology lupus arthritis blood dermatomyositis druginduced hemophagocytic hlh lymphohistiocytosis oncology product reactions sle symptoms algorithm anemia
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
FLAGS - In all cases ... Non-accidental Injury ... splenomegaly, abnormal neurology ... cell disease Rheumatology ... Peds #Pediatrics #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... : 70 years old, ... ~10,000 new cases ... #Management #treatment ... #hematology #oncology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... Inverse Gottron’s sign ... increases and ILD ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... may be normal in mild ... cases) • PT/INR ... Chronic Management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Ischemic Liver, IBD ... coagulation and other causes ... Vasculitis • Injury ... pathophysiology #hematology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
knees, shoulders Signs ... • Ultrasound Diagnosis ... : CLINICAL DIAGNOSIS ... Certolizumab, Golimumab), IL ... #management #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
autoantibodies that will cause ... permeability Diagnosis ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... Auto-amplification loop Diagnosis ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Prognosis: Usually mild ... Discontinuation of causal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
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