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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Lupus Erythematosus ... #Lupus #Erythematosus ... #SLE #hematology ... differential #diagnosis
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Hypersensitivity vasculitis ... lesions • Discoid ... lupus erythematosus ... #dermatology ... #rashes #differential
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
dermatomyositis, SLE ... leukocytoclastic vasculitis ... myelodysplastic #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... #SLE #systemic
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
and C viruses. systemic ... lupus erythematosus ... in absence of skin ... lesions BWH ... #vasculitis #differential
Vasculitis: In this instance, the vasculitic skin lesions were secondary to Haemophilus endocarditis.
Photo credit, Josh Fierer,
Vasculitis: In this ... skin lesions were ... UCSD Catalog of Clinical ... Images #Clinical ... #Photo #Dermatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Lesions == Macules ... • Xerosis (dry skin ... Lesion / Systemic ... Blood Glucose: • Diabetes ... #generalized #dermatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... Secondary: CTD: SLE ... Skin Findings: ... #skin #dermatology ... differential #diagnosis
Vascular Skin Lesions - Differential Diagnosis Algorithm
 - Petechiae < 0.2 cm diameter
 - Purpura 0.2
Vascular Skin Lesions ... - Differential ... discolorations of skin ... #SkinRash #dermatology ... #Differential #
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
disease (10%) : SLE ... #dermpath #dermatology ... semiology #signs #lesions ... #diagnosis #clinical ... #differential