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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... in Systemic Lupus ... #diseases #SLE ... Erythematosus #venn #nephrology ... #nephritis #classification
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Ketoacidosis: Diabetic ... oxoproline) • Renal ... Renal acidosis ... Hypokalemia ... diagnosis #causes #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
gastrointestinal K loss • Renal ... • Renal tubular ... acidosis (type ... Ureterosigmoidostomy, Diabetic ... algorithm #causes #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
(Uncontrolled diabetes ... - Metabolic acidosis ... deficiency • Renal ... insufficiency/Failure • SLE ... potassium #high #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
losses, Diuretic ... tubal acidosis ... hormone secretion Hypervolemia ... failure Hypervolemia ... Algorithm #Causes #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of ... Acquired - Primary renal ... , hypercalcemia) ... #Classification ... #Types #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
(Uncontrolled diabetes ... - Metabolic acidosis ... deficiency • Renal ... insufficiency/Failure • SLE ... potassium #high #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
post-hypothermia • ↓ Renal ... Excretion: - Renal ... 15 suggests ↓ renal ... and Elimination (see ... Treatment #potassium #nephrology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... or 0.5 g/day → renal ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology #nephrology
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Acidosis B. ... diseases: syßtemic lupus ... erythematosus (SLE ... Diabetes, diabetic ... High #Potassium #Classification