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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... #diseases #SLE ... Erythematosus #venn #nephrology ... #nephritis #classification ... #types #rheumatology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... failure • Chronic ... • Drugs • Diabetic ... 1 #Hyperkalemia ... Diagnosis #algorithm #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of ... Acquired - Primary renal ... , hypercalcemia) ... #Classification ... #Types #Nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Ketoacidosis: Diabetic ... failure (acute and chronic ... Renal acidosis ... Chronic progressive ... diagnosis #causes #nephrology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... or 0.5 g/day → renal ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
trauma - Ischemic colonic ... (Uncontrolled diabetes ... insufficiency/Failure • SLE ... • Type IV RTA ... potassium #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
trauma - Ischemic colonic ... (Uncontrolled diabetes ... insufficiency/Failure • SLE ... • Type IV RTA ... potassium #high #nephrology
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
diseases: syßtemic lupus ... erythematosus (SLE ... Diabetes, diabetic ... Chronic kidney disease ... High #Potassium #Classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Kikuchi disease • Type-I ... APLA/LAC: • Renal ... : • Chronic B-cell
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Excretion: - Renal ... Aldosterone, RTA Type ... 15 suggests ↓ renal ... and Elimination (see ... Treatment #potassium #nephrology