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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
in Systemic Lupus ... #diseases #SLE ... #Systemic #Lupus ... Erythematosus #venn #nephrology ... #nephritis #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... hemolysis • Renal ... #Criteria #SLE ... #Systemic #Lupus
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of ... Acquired - Primary renal ... , hypercalcemia) ... #Classification ... #Types #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
(Uncontrolled diabetes ... deficiency • Renal ... insufficiency/Failure • SLE ... Type IV RTA • Renal ... potassium #high #nephrology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... or 0.5 g/day → renal ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
(Uncontrolled diabetes ... deficiency • Renal ... insufficiency/Failure • SLE ... Type IV RTA • Renal ... potassium #high #nephrology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Abnormality • SLE ... heart failure • Diabetes ... discoloration) • Chronic renal ... #Secondary #dermatology
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
lupus erythematosus ... (SLE), sickle cell ... Diabetes, diabetic ... Tubulointerstitial diseases: SLE ... High #Potassium #Classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Neuropsychiatric systemic ... APLA/LAC: • Renal ... #Systemic #Lupus
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
post-hypothermia • ↓ Renal ... Excretion: - Renal ... 15 suggests ↓ renal ... and Elimination (see ... Treatment #potassium #nephrology