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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Lupus Erythematosus ... #SLE #hematology ... #differential #diagnosis ... #causes
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... #SLE #CNS #neurology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... • Nephrotic syndrome ... #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
- Differential Diagnosis ... Hypomagnesemia with secondary ... renal transplant, Diuretic ... #causes #nephrology ... #magnesium #low
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Positive in 60-80% of cases ... 60-80% - Low ... #lupus #Systemic
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
- Differential Diagnosis ... Stevens-Johnson Syndrome ... necrolysis - Systemic ... lupus erythematosus ... #Algorithm #causes
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... Inflammatory causes ... • Systemic lupus ... #neurology #inflammatory ... #differential #diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
and Primary Causes ... Blood Glucose: • Diabetes ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #dermatology #Differential
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential Diagnosis ... suggests either secondary ... Ureterosigmoidostomy, Diabetic ... #differential #diagnosis ... #nephrology #potassium
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... Lupus Erythematosus ... Hypocomplementemia #Low ... CHAMPS #Mnemonic #diagnosis