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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Thrombotic Microangiopathies ... In Systemic Lupus ... Lupusreference #TMAs #Thrombotic ... Erythematosus #SLE ... #hematology #rheumatology
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Thrombotic Microangiopathy ... - TTP VS HUS ... high rates of morbidity ... testing for TTP #Thrombotic ... Diagnosis #Table #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... vasculopathy, thrombosis ... Induction Rx: high-dose ... #CNS #neurology ... #rheumatology #
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... catastrophic APS, SRC, SLE ... There is a high ... @AnnKumfer #Thrombotic ... Microangiopathy #TMAs #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... complements and a high ... Non-autoimmune rheumatologic ... : Drug induced SLE ... Erythematosus #Diagnosis #Rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
syndrome - Thrombotic ... microangiopathy: Thrombotic ... uremic syndrome (HUS ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
= atypical HUS; ... glomerulonephritis; TTP = thrombotic ... red blood cells/high-power ... Diabetic nephropathy ... nephrotic #syndrome #nephrology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
PE) or arterial thrombosis ... Confirmatory test ↑Se ... wait to treat if high ... or high likelihood ... Management #Treatment #Hematology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... cirrhosis - TTP/HUS ... Glucocorticoid, high ... diagnosis #management #rheumatology