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rheumatology erythematosus management autoantibodies differential types vasculitis activation allergy antinuclear associations causes clinical comparison criteria cryoglobulinemia cryoglobulins cutaneous druginduced eschar
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... lupus nephritis ... autoantibodies #Systemic ... #diagnosis #rheumatology ... #table #ANA
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... #Criteria #SLE ... #Systemic #Lupus ... Erythematosus #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... (SLE): ANA (anti-nuclear ... • Scleroderma (Systemic ... #Rheumatology #diagnosis ... #associations #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... months to years) Systemic ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Differential Diagnosis ... #Systemic #Lupus ... Erythematosus #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) • ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... systemic lupus ... Hypersensitivity #Types #Classification ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... vaso-occlusive ... SLE) • Urinalysis ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Labs/Diagnosis: ... lupus erythematosus ... (SLE), rheumatoid ... #types #classification
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
syndrome (GBS), systemic ... lupus erythematosus ... (SLE), polymyositis ... syndrome (LEMS), systemic ... Atorvastatin Diagnosis
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